Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16853997 | 0.92 | MKNK2 (0.55) | MKNK2MKNK1MAPK14EIF4E | |
| SCHEMBL16854164 | 0.90 | MKNK2 (0.49) | MKNK2MKNK1MAPK14MAPK11EIF4E | |
| SCHEMBL16854061 | 0.89 | MKNK2 (0.51) | MKNK2MKNK1MAPK14MAPK11EIF4E | |
| SCHEMBL16854047 | 0.89 | MKNK2 (0.41) | MKNK2MKNK1MAPK14MAPK11EIF4E | |
| SCHEMBL16854032 | 0.86 | MKNK2 (0.51) | MKNK2MKNK1 | |
| SCHEMBL16854074 | 0.86 | MKNK2 (0.49) | MKNK2MKNK1MAPK14EIF4E | |
| SCHEMBL16854041 | 0.86 | MKNK2 (0.52) | MKNK2MKNK1 | |
| SCHEMBL16854081 | 0.86 | MKNK2 (0.49) | MKNK2MKNK1MAPK14MAPK11EIF4E | |
| SCHEMBL16854052 | 0.85 | MAPK14 (0.42) | MAPK14MAPK11 | |
| SCHEMBL16854059 | 0.81 | MKNK2 (0.55) | MKNK2MKNK1EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091156-A1 | SULFOXIMINE SUBSTITUTED PYRROLOTRIAZINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |