Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854050 | 0.88 | TYK2 (0.44) | TYK2MAPK14MAPK11KDR | |
| SCHEMBL16854052 | 0.86 | MAPK14 (0.42) | TYK2MAPK14MAPK11MAP2K1 | |
| SCHEMBL16854046 | 0.86 | TYK2 (0.42) | TYK2MAPK14MAPK11MAP2K1 | |
| SCHEMBL16854068 | 0.84 | TYK2 (0.40) | TYK2MAPK14MAPK11 | |
| SCHEMBL16854067 | 0.84 | TYK2 (0.40) | TYK2MAPK14MAPK11 | |
| SCHEMBL16854081 | 0.81 | MKNK2 (0.49) | MAPK14MAPK11KDR | |
| SCHEMBL16854035 | 0.75 | MKNK2 (0.41) | MAPK14MAPK11KDR | |
| SCHEMBL2394406 | 0.74 | MKNK2 (0.66) | — | |
| SCHEMBL12257366 | 0.74 | MKNK2 (0.66) | — | |
| SCHEMBL2391758 | 0.74 | MKNK2 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091156-A1 | SULFOXIMINE SUBSTITUTED PYRROLOTRIAZINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |