Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 10/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.48 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857910 | 0.89 | EGLN1 (0.42) | TNKSTNKS2PARP2PARP1EGLN1 | |
| SCHEMBL16857831 | 0.87 | EGLN1 (0.46) | TNKSTNKS2PARP2PARP1EGLN1 | |
| SCHEMBL16857800 | 0.87 | EGLN1 (0.42) | EGLN1 | |
| SCHEMBL16857734 | 0.85 | EGLN1 (0.51) | TNKSTNKS2PARP1EGLN1 | |
| SCHEMBL16857803 | 0.85 | EGLN1 (0.51) | TNKSTNKS2PARP1EGLN1 | |
| SCHEMBL16857710 | 0.85 | EGLN1 (0.40) | EGLN1GUSB | |
| SCHEMBL3030810 | 0.85 | EGLN1 (0.55) | TNKSTNKS2PARP2PARP1EGLN1 | |
| SCHEMBL16857836 | 0.84 | EGLN1 (0.39) | EGLN1 | |
| SCHEMBL16857735 | 0.84 | EGLN1 (0.40) | PARP1EGLN1 | |
| SCHEMBL16857795 | 0.84 | EGLN1 (0.39) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | claimed |