SCHEMBL16857722

SCHEMBL16857722

O=C(O)Oc1cnn(-c2nc3cc(S(=O)(=O)c4ccccc4Cl)ccc3c(=O)[nH]2)c1

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 20/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16857901 0.89 EGLN1 (0.44) EGLN1
SCHEMBL16857856 0.88 EGLN1 (0.48) EGLN1
SCHEMBL3036298 0.87 EGLN1 (0.61) EGLN1
SCHEMBL16857769 0.86 EGLN1 (0.58) EGLN1
SCHEMBL16857920 0.82 EGLN1 (0.52) EGLN1
SCHEMBL16857919 0.81 EGLN1 (0.48) EGLN1
SCHEMBL16857883 0.81 EGLN1 (0.53) EGLN1
SCHEMBL16857874 0.81 EGLN1 (0.52) EGLN1
SCHEMBL16857808 0.80 EGLN1 (0.45) EGLN1
SCHEMBL16857907 0.80 EGLN1 (0.48) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396316-B1 QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2015-07-01 EP claimed