Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 14/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857959 | 0.87 | AVPR1B (0.41) | AVPR1BUSP2ALDH1A1LMNAHTT | |
| SCHEMBL16857971 | 0.87 | MAPT (0.46) | AVPR1BALDH1A1LMNAGAAMAPT | |
| SCHEMBL5578374 | 0.82 | MAPK1 (0.48) | AVPR1BLMNAL3MBTL1KMT2AGAA | |
| SCHEMBL5578286 | 0.82 | AVPR1B (0.45) | AVPR1BNPC1RAB9AUSP2ALDH1A1 | |
| SCHEMBL5578463 | 0.79 | AVPR1B (0.59) | AVPR1BALDH1A1LMNAALOX15GAA | |
| SCHEMBL5578430 | 0.79 | LMNA (0.43) | AVPR1BALDH1A1LMNAKMT2AGAA | |
| SCHEMBL7471393 | 0.75 | AVPR1B (0.49) | AVPR1B | |
| SCHEMBL16857968 | 0.75 | MAPT (0.47) | AVPR1BALDH1A1LMNAHTTKMT2A | |
| SCHEMBL1465263 | 0.74 | AVPR1B (0.39) | AVPR1BALDH1A1GAA | |
| SCHEMBL16857970 | 0.74 | GAA (0.42) | AVPR1BALDH1A1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487505-B2 | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-11-08 | — | — | US | claimed |
| EP-1667993-B1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | ABBVIE DEUTSCHLAND (DE) | 2015-07-01 | — | — | EP | claimed |