Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5252190 | 0.86 | ADAM17 (0.52) | ADAM17TNF | |
| SCHEMBL16820515 | 0.84 | ADAM17 (0.47) | ADAM17TNF | |
| SCHEMBL16820518 | 0.84 | ADAM17 (0.47) | ADAM17TNF | |
| SCHEMBL16858382 | 0.83 | ADAM17 (0.47) | ADAM17 | |
| SCHEMBL16820419 | 0.83 | ADAM17 (0.47) | ADAM17TNF | |
| SCHEMBL16820418 | 0.83 | ADAM17 (0.47) | ADAM17TNF | |
| SCHEMBL16850270 | 0.80 | CRBN (0.44) | ADAM17OPRM1OPRL1OPRK1 | |
| SCHEMBL16820474 | 0.80 | ADAM17 (0.44) | ADAM17TNF | |
| SCHEMBL16820473 | 0.80 | ADAM17 (0.44) | ADAM17TNF | |
| SCHEMBL16850271 | 0.80 | CRBN (0.44) | ADAM17OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095052-A1 | ISOINDOLIN-1-ONES AS MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) INHIBITORS | CONTROLLED CHEMICALS, INC. (US) | 2015-06-25 | — | — | WO | disclosed |