Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29430391 | 0.72 | PIK3CD (0.51) | FGFR1FGFR2USP7PIK3CDPIK3CB | |
| SCHEMBL4476790 | 0.72 | PIK3CD (0.51) | FGFR1FGFR2USP7PIK3CDPIK3CB | |
| SCHEMBL588382 | 0.71 | PKMYT1 (0.49) | FGFR1FGFR2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL31672542 | 0.69 | KDR (0.64) | — | |
| SCHEMBL10151186 | 0.69 | KDR (0.64) | — | |
| SCHEMBL2745386 | 0.68 | DHFR (0.59) | FGFR1FGFR2USP7PIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL4478858 | 0.67 | DHFR (0.57) | FGFR1FGFR2USP7PIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL29430410 | 0.67 | DHFR (0.57) | FGFR1FGFR2USP7PIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL4478855 | 0.66 | DHFR (0.56) | FGFR1FGFR2USP7PIK3CDPIK3CB | |
| SCHEMBL6810597 | 0.63 | KDR (0.41) | FGFR1FGFR2FGFR3LCKDDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311825-A1 | Pyrimidineamines as angiogenesis modulators | GlaxoSmithKline LLC (US) | 2011-04-20 | — | — | EP | claimed |