Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16889003 | 1.00 | ADORA2A (0.43) | ADORA2AGBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL8783242 | 0.88 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL7534021 | 0.87 | SIGMAR1 (0.46) | SIGMAR1SPHK2SPHK1 | |
| SCHEMBL7534024 | 0.87 | SIGMAR1 (0.46) | SIGMAR1SPHK2SPHK1 | |
| SCHEMBL28303175 | 0.85 | ADORA2A (0.44) | ADORA2ASIGMAR1 | |
| SCHEMBL29538556 | 0.85 | ADORA2A (0.44) | ADORA2ASIGMAR1 | |
| SCHEMBL16879202 | 0.84 | SIGMAR1 (0.44) | GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL16879200 | 0.84 | SIGMAR1 (0.44) | GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL16878916 | 0.84 | SIGMAR1 (0.44) | GBA1SIGMAR1SPHK2SPHK1 | |
| SCHEMBL16878915 | 0.84 | SIGMAR1 (0.44) | GBA1SIGMAR1SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015103527-A1 | MODULATORS OF REV-ERB | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-07-09 | — | — | WO | disclosed |