Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 4/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13311322 | 1.00 | CCR4 (0.59) | CCR4HRH4HTR3ATRPC3TRPC6 | |
| SCHEMBL12440601 | 0.94 | CCR4 (0.59) | CCR4HRH4HTR3ATRPC3TRPC6 | |
| SCHEMBL13144692 | 0.93 | CCR4 (0.56) | CCR4HRH4HTR3ATRPC3TRPC6 | |
| SCHEMBL13348079 | 0.87 | CCR4 (0.56) | CCR4HRH4HTR3ATRPC3TRPC6 | |
| SCHEMBL16768158 | 0.86 | CCR4 (0.64) | CCR4HRH4HTR3ATRPC3TRPC6 | |
| SCHEMBL13451284 | 0.85 | CCR4 (0.59) | CCR4HRH4HTR3ATRPC3TRPC6 | |
| SCHEMBL3095318 | 0.85 | CCR4 (0.73) | CCR4EGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL3073062 | 0.84 | CCR4 (0.72) | CCR4EGFRFGFR1FLT1FLT4 | |
| SCHEMBL13144690 | 0.83 | CCR4 (0.53) | CCR4HRH4HTR3A | |
| SCHEMBL17525991 | 0.83 | CCR4 (0.82) | CCR4HRH4HTR3AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046601-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-02-18 | — | — | US | disclosed |
| US-9221836-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-12-29 | — | — | US | disclosed |
| US-20150191486-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191486-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | REN, AGT, ACE | CCR4 3946/4885HRH4 811/4885HTR3A 1943/4885 |
| US-20160046601-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | REN, AGT, ACE | CCR4 3946/4885HRH4 811/4885HTR3A 1943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.