Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16887681 | 0.85 | LMNA (0.37) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL16887652 | 0.85 | LMNA (0.37) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL16875354 | 0.84 | CYP2C19 (0.42) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL16875355 | 0.84 | CYP2C19 (0.42) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL16892289 | 0.82 | GRM2 (0.37) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL16887659 | 0.82 | LMNA (0.35) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL16887638 | 0.81 | LMNA (0.34) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL13274121 | 0.79 | — | — | |
| SCHEMBL16887682 | 0.78 | LMNA (0.41) | LMNAPLGPLATGRM2GRM3 | |
| SCHEMBL21242166 | 0.78 | LMNA (0.41) | LMNAPLGPLATGRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015103509-A1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |