Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 12/20 | 0.72 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19132755 | 0.86 | EPHX2 (0.60) | EPHX2EPHX1MAPK1GAA | |
| SCHEMBL19132802 | 0.85 | EPHX2 (0.54) | EPHX2EPHX1MAPK1RORCGAA | |
| SCHEMBL4109537 | 0.84 | EPHX2 (1.00) | EPHX2EPHX1 | |
| SCHEMBL3317488 | 0.83 | EPHX2 (0.61) | EPHX2EPHX1MAPK1CYP2D6HRH3 | |
| SCHEMBL18217021 | 0.79 | EPHX2 (0.49) | EPHX2EPHX1MAPK1RORCREV1 | |
| SCHEMBL16888280 | 0.79 | RORC (0.50) | EPHX2MAPK1RORCKMT2ACYP2D6 | |
| SCHEMBL14276927 | 0.79 | EPHX2 (0.70) | EPHX2EPHX1MAPK1KMT2ACYP2D6 | |
| SCHEMBL21738155 | 0.77 | MAPK1 (0.49) | EPHX2EPHX1MAPK1REV1KMT2A | |
| SCHEMBL19132818 | 0.77 | POLB (0.47) | EPHX2MAPK1KMT2AGAA | |
| SCHEMBL19132792 | 0.77 | POLB (0.47) | EPHX2MAPK1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708253-B2 | Cyclohexyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| WO-2015103507-A1 | CYCLOHEXYL SULFONE RORϒ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |