SCHEMBL16888178

SCHEMBL16888178

O=S(=O)(c1ccc(F)cc1)C1(c2ccc(C(OCc3ccccc3)(C(F)(F)F)C(F)(F)F)cc2)CCCCC1

nearest known ligand 0.98

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.98
NR1I2 O75469 6/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16891754 0.99 RORC (1.00) RORCNR1I2
SCHEMBL16891653 0.93 RORC (1.00) RORCNR1I2
SCHEMBL18204879 0.93 RORC (0.88) RORCNR1I2
SCHEMBL16891644 0.91 RORC (1.00) RORCNR1I2
SCHEMBL16876962 0.90 RORC (0.83) RORCNR1I2
SCHEMBL16891634 0.90 RORC (1.00) RORCNR1I2
SCHEMBL16876952 0.89 RORC (0.82) RORCNR1I2
SCHEMBL18213863 0.89 RORC (0.85) RORCNR1I2
SCHEMBL16891636 0.89 RORC (1.00) RORCNR1I2
SCHEMBL16880406 0.89 RORC (1.00) RORCNR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106061947-B Cyclohexyl sulfone ROR gamma modulators 百时美施贵宝公司 2019-12-03 CN disclosed
WO-2015103507-A1 CYCLOHEXYL SULFONE RORϒ MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-07-09 WO disclosed