Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.56 |
| ▸ | ACVR1B | P36896 | 14/20 | 0.56 |
| ▸ | ACVRL1 | P37023 | 10/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879277 | 0.81 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1CYP3A4 | |
| SCHEMBL16879809 | 0.81 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879186 | 0.77 | TGFBR1 (0.72) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879709 | 0.76 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL18219801 | 0.75 | TGFBR1 (0.68) | TGFBR1ACVR1BACVRL1ACVR1CYP3A4 | |
| SCHEMBL16879552 | 0.75 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879826 | 0.74 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1ACVR1CYP3A4 | |
| SCHEMBL16879672 | 0.74 | TGFBR1 (0.66) | TGFBR1ACVR1BACVRL1ACVR1CYP3A4 | |
| SCHEMBL16879389 | 0.74 | TGFBR1 (0.54) | TGFBR1ACVR1BACVRL1ACVR1CYP3A4 | |
| SCHEMBL20397408 | 0.74 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015103355-A1 | COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-07-09 | — | — | WO | disclosed |