Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1689078 | 0.93 | MAPT (0.61) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL5611521 | 0.93 | MAPT (0.61) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL1688969 | 0.92 | MAPT (0.49) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL5611869 | 0.92 | MAPT (0.49) | MAPTMEN1KMT2AHSP90AA1KDM4E | |
| SCHEMBL1688889 | 0.92 | MAPT (0.49) | MAPTMEN1KMT2AHSP90AA1KDM4E | |
| SCHEMBL1689122 | 0.90 | MAPT (0.48) | MAPTMEN1KMT2AHSP90AA1KDM4E | |
| SCHEMBL5611994 | 0.89 | MAPT (0.49) | MAPTMEN1KMT2AHSP90AA1KDM4E | |
| SCHEMBL1689317 | 0.89 | ALDH1A1 (0.59) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5611678 | 0.89 | MAPT (0.52) | MAPTMEN1KMT2AHSP90AA1KDM4E | |
| SCHEMBL1689243 | 0.88 | MAPT (0.51) | MAPTMEN1KMT2AHSP90AA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | claimed |
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | disclosed |