Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ICMT | O60725 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17553736 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL16889141 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL19497532 | 0.78 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL16885324 | 0.78 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL16885314 | 0.78 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL17553735 | 0.77 | — | — | |
| SCHEMBL24517556 | 0.75 | — | — | |
| SCHEMBL24777513 | 0.72 | TSHR (0.41) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL27003815 | 0.72 | TSHR (0.41) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL24708218 | 0.72 | TSHR (0.41) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242984-B2 | Pyrazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150191461-A1 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191461-A1 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, LCK | ALDH1A1 2112/4885KDM4E 1293/4885SMN1; SMN2 4721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.