SCHEMBL16889408

SCHEMBL16889408

Cc1cccnc1-c1cc2c3c(c1)Oc1cc(-c4ccccc4)ccc1B3c1ccc(-c3ccccc3)cc1O2

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.40
TRPV1 Q8NER1 5/20 0.33
CNR2 P34972 1/20 0.33
DHODH Q02127 1/20 0.33
GAA P10253 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ABL1 P00519 1/20 0.32
PDK1 Q15118 2/20 0.32
EGLN1 Q9GZT9 1/20 0.31
GRIA2 P42262 1/20 0.31
EPHX2 P34913 1/20 0.31
PTGS1 P23219 1/20 0.30
PTGS2 P35354 1/20 0.30
METAP2 P50579 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16889538 0.96 CYP2A6 (0.38) CYP2A6TRPV1CNR2DHODHGAA
SCHEMBL16890090 0.82 RAB9A (0.38) CYP2A6GAAL3MBTL1
SCHEMBL16889395 0.80 DYRK1A (0.41)
SCHEMBL16889607 0.80 PTGS1 (0.36) CYP2A6TRPV1CNR2DHODHPDK1
SCHEMBL16889687 0.80 CA12 (0.35) GAAL3MBTL1PTGS2
SCHEMBL22054892 0.79 MEN1 (0.38) DHODHGAAL3MBTL1
SCHEMBL23188787 0.78 SRC (0.35) DHODHGAAL3MBTL1
SCHEMBL16889953 0.78 CYP2A6 (0.35) CYP2A6TRPV1CNR2ABL1GRIA2
SCHEMBL16890505 0.78 CA12 (0.34) GAAL3MBTL1
SCHEMBL16889398 0.77 CYP11B1 (0.47) CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3345911-A1 POLYCYCLIC AROMATIC COMPOUNDS AND THEIR USE AS ORGANIC DEVICE MATERIAL Kwansei Gakuin Educational Foundation (JP) 2018-07-11 EP disclosed
WO-2015102118-A1 POLYCYCLIC AROMATIC COMPOUND 学校法人関西学院 2015-07-09 WO disclosed