Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482434 | 1.00 | ELANE (0.54) | ELANEMCL1SCN4ARIPK1CTSC | |
| SCHEMBL20482162 | 1.00 | ELANE (0.54) | ELANEMCL1SCN4ARIPK1CTSC | |
| SCHEMBL5357416 | 0.95 | ELANE (0.49) | ELANEMCL1SCN4ARIPK1CTSC | |
| SCHEMBL14994604 | 0.95 | ELANE (0.49) | ELANEMCL1SCN4ARIPK1CTSC | |
| Hydrochloric Acid SCHEMBL1251429 | 0.93 | ELANE (0.48) | ELANEMCL1CTSCCYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL5423645 | 0.91 | ELANE (0.47) | ELANEMCL1SCN4ARIPK1CTSC | |
| Trifluoroacetic Acid SCHEMBL5423648 | 0.91 | ELANE (0.47) | ELANEMCL1SCN4ARIPK1CTSC | |
| SCHEMBL28854337 | 0.90 | ELANE (0.49) | ELANERIPK1CTSCKMT2ANPC1 | |
| SCHEMBL28854336 | 0.90 | ELANE (0.49) | ELANERIPK1CTSCKMT2ANPC1 | |
| SCHEMBL27623273 | 0.84 | ELANE (0.43) | ELANESCN4ARIPK1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325512-A | The method for being used to prepare chiral pyrrolidine -2- base carbinol derivatives | 豪夫迈·罗氏有限公司 | 2019-10-11 | — | — | CN | disclosed |
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| CN-103079562-A | BACE inhibitors for use in the treatment of diabetes | HOFFMANN LA ROCHE | 2013-05-01 | — | — | CN | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
| CN-102260265-A | Hexahydro-pyrrole[3,4-b] pyrrole derivative, its preparation method and application | — | 2011-11-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053200-A1 | BACE 2 INHIBITORS | BACE2, BACE1, PSEN2 | ELANE 3069/4885MCL1 3253/4885SCN4A 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.