Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | CCKBR | P32239 | 2/20 | 0.69 |
| ▸ | PDE5A | O76074 | 5/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17520531 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL25282368 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL16491970 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL9476492 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL18212308 | 0.90 | KDM4E (0.82) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL28698432 | 0.89 | KDM4E (0.80) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL29817675 | 0.87 | KDM4E (0.77) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL29817676 | 0.87 | KDM4E (0.77) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL2216780 | 0.86 | KDM4E (0.98) | KDM4EHSD17B10TSHRHTTALDH1A1 | |
| SCHEMBL16892184 | 0.86 | KDM4E (0.98) | KDM4EHSD17B10TSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |
| CN-108969770-B | Dipeptide modified 1-methyl-3-hydroxymethyl-tetrahydro-beta-carboline, synthesis and application thereof | 首都医科大学 | 2021-07-27 | — | — | CN | disclosed |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | NANKAI UNIVERSITY (CN) | 2019-02-19 | — | — | US | disclosed |
| US-20170210743-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | Universitätsklinikum Jena (DE) | 2017-07-27 | — | — | US | disclosed |
| US-20170210743-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | Universitätsklinikum Jena (DE) | 2017-07-27 | — | — | US | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| WO-2015101206-A1 | Β-CARBOLINE, DIHYDRO-Β-CARBOLINE AND TETRAHYDRO-Β-CARBOLINE ALKALOID DERIVATIVES AND METHOD FOR PREPARING SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | 南开大学 | 2015-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | DDT, NOTUM, DDAH1 | KDM4E 1695/4885HSD17B10 769/4885TSHR 3772/4885 |
| US-20170210743-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | HDAC6, HDAC5, HDAC4 | KDM4E 676/4885HSD17B10 456/4885TSHR 3508/4885 |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | DDT, ZC3HAV1, NOTUM | KDM4E 1731/4885HSD17B10 775/4885TSHR 3653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.