Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 8/20 | 0.81 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.58 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | IGSF11 | Q5DX21 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16903569 | 0.95 | TLR4 (0.79) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896110 | 0.94 | TLR4 (0.78) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896133 | 0.94 | TLR4 (0.77) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16906386 | 0.92 | TLR4 (0.79) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896193 | 0.90 | TLR4 (1.00) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL29548800 | 0.90 | TLR4 (1.00) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896224 | 0.89 | TLR4 (0.75) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896088 | 0.89 | TLR4 (0.76) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896202 | 0.89 | TLR4 (0.76) | TLR4APOBEC3AAPOBEC3GKDM4EMEN1 | |
| SCHEMBL16896166 | 0.84 | TLR4 (0.56) | TLR4MEN1USP2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505768-B2 | Compositions and methods for modulating TLR4 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150197527-A1 | COMPOSITIONS AND METHODS FOR MODULATING TLR4 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197527-A1 | COMPOSITIONS AND METHODS FOR MODULATING TLR4 | TLR4, TLR3, TLR6 | TLR4 1/4885APOBEC3A 2847/4885APOBEC3G 2301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.