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TLR6

Toll-like receptor 6 · Q9Y2C9 · TLR6 on Sugi Atlas →

3,907 patent compounds predicted against TLR6, 2,885 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3308886 SCHEMBL3308886 0.78 2/20
SCHEMBL524859 SCHEMBL524859 0.67 2/20
SCHEMBL2317614 SCHEMBL2317614 0.61 2/20
SCHEMBL3776981 SCHEMBL3776981 0.61 2/20
SCHEMBL948814 SCHEMBL948814 0.56 2/20
SCHEMBL5458 SCHEMBL5458 0.55 2/20
SCHEMBL3279515 SCHEMBL3279515 0.52 2/20
Potassium Ion Potassium Ion (SCHEMBL1002904) 0.49 2/20
SCHEMBL16004 SCHEMBL16004 1.00 1/20
SCHEMBL929734 SCHEMBL929734 1.00 1/20
SCHEMBL2730154 SCHEMBL2730154 0.73 1/20
Vanillin Vanillin (SCHEMBL1934531) 0.71 1/20
SCHEMBL1527154 SCHEMBL1527154 0.69 1/20
SCHEMBL3406649 SCHEMBL3406649 0.69 1/20
SCHEMBL3864807 SCHEMBL3864807 0.68 1/20
SCHEMBL60623 SCHEMBL60623 0.67 1/20
SCHEMBL3421185 SCHEMBL3421185 0.67 1/20
SCHEMBL172818 SCHEMBL172818 0.66 1/20
SCHEMBL738533 SCHEMBL738533 0.66 1/20
2-Methoxybenzaldehyde 2-Methoxybenzaldehyde (SCHEMBL66490) 0.64 1/20

Clinical trials — most relevant to TLR6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy PHASE4UNKNOWN
Reducing Abundance of Human Papilloma Virus in Women by Taking Probiotic PHASE2/PHASE3WITHDRAWN
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis PHASE3COMPLETED
Single-step Antigen Loading and TLR Activation of Dendritic Cells in Melanoma Patients PHASE1/PHASE2COMPLETED
Toll-like Receptor (TLR) Ligand Matured Dendritic Cell Vaccination in Melanoma Patients PHASE1/PHASE2COMPLETED
A Study Assessing Safety, Tolerability, and Efficacy of INNA-051 in Preventing Respiratory Illness Due to Viral Infections in Healthy Adults 18 to 45 Years of Age PHASE2RECRUITING
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19 PHASE2UNKNOWN
Safety/Efficacy Study of Bovine Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis PHASE2COMPLETED
The Effects of GLA on Human Volunteers PHASE1COMPLETED
Polyinosinic-Polycytidylic Acid-poly-L-lysine Carboxymethylcellulose (Poly-ICLC) in Healthy Volunteers PHASE1COMPLETED
Neoadjuvant Imiquimod Immunotherapy for Oral Cancer EARLY_PHASE1COMPLETED
Expression of Toll-like Receptors 3 , 7 and 9 in Peripheral Blood Mononuclear Cells of COVID-19 Patients nanUNKNOWN
Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis nanCOMPLETED
Efficacy of Intranasal Probiotic Treatment to Reduce Severity of Symptoms in COVID19 Infection nanCOMPLETED
Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery nanCOMPLETED
Bacteremia in Intensive Care Unit (ICU) nanUNKNOWN
Impact of Nasal Saline Irrigations on Viral Load in Patients With COVID-19 nanCOMPLETED
Deep Phenotyping of Cutaneous Lupus Erythematosus nanUNKNOWN
Neuro-Immune Interactions in the Gut nanCOMPLETED
TLR4 Polymorphisms and Risk of Skin Cancer nanCOMPLETED
MicroRNAs and Cytokines in Peri-Implantitis Tissue nanUNKNOWN
Probiotics in the Prevention of Hepatocellular Carcinoma in Cirrhosis nanUNKNOWN
Ventilator-Associated Pneumonia (VAP) in Intensive Care Unit (ICU) nanUNKNOWN
Establishing a Diagnostic Test for Non-tuberculous Mycobacteria Lung Infection Using Non-tuberculous Mycobacteria Antigen Stimulation Test: From Immune Base, Standardized Setup to Validation nanUNKNOWN
MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease nanCOMPLETED
Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock nanCOMPLETED
The Suppression of Toll Like Receptors by Insulin nanCOMPLETED
Study of the Activation of Proinflammatory Pathways of Toll-like Receptors in Schizophrenia Patients nanCOMPLETED
Effect of Alcohol Consumption on Markers of Inflammation nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TLR6 binder may also engage these)

ProteinNameSimilarity
Q704V6 — 0.998 Q704V6 →
Q0ZUL9 — 0.993 Q0ZUL9 →
TLR1 Toll-like receptor 1 0.990 landscape →
Q9EPW9 — 0.985 Q9EPW9 →
Q9DD78 — 0.984 Q9DD78 →
Q9EPQ1 — 0.981 Q9EPQ1 →
B5T267 — 0.977 B5T267 →
B2LT61 — 0.976 B2LT61 →
Q2PZH4 — 0.975 Q2PZH4 →
Q689D1 — 0.974 Q689D1 →
Q95LA9 — 0.974 Q95LA9 →
Q95M53 — 0.973 Q95M53 →
Q6T752 — 0.973 Q6T752 →
Q2V897 — 0.973 Q2V897 →
Q0GC71 — 0.972 Q0GC71 →
B2LT64 — 0.972 B2LT64 →
B3Y618 — 0.972 B3Y618 →
B2LT62 — 0.970 B2LT62 →
TLR2 Toll-like receptor 2 0.970 landscape →
B3Y615 — 0.969 B3Y615 →
B3Y613 — 0.969 B3Y613 →
B3Y614 — 0.969 B3Y614 →
Q6GV17 — 0.969 Q6GV17 →
TLR7 Toll-like receptor 7 0.968 landscape →
Q9BXR5 — 0.967 Q9BXR5 →
Q9DGB6 — 0.965 Q9DGB6 →
B2LT65 — 0.965 B2LT65 →
P58681 — 0.961 P58681 →
Q9R1F8 — 0.961 Q9R1F8 →
Q9QUN7 — 0.960 Q9QUN7 →