Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | SLC5A1 | P13866 | 8/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 8/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896942 | 0.92 | L3MBTL1 (0.44) | PIK3CGSLC5A1SLC5A2CYP3A4CYP2C9 | |
| SCHEMBL16896884 | 0.90 | BRD4 (0.41) | PIK3CGCYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL16896893 | 0.83 | BRD4 (0.44) | CYP3A4CYP2C9CYP2D6CYP2C19EZH2 | |
| SCHEMBL16896867 | 0.83 | BRD4 (0.41) | CYP3A4CYP2C9EZH2BRD4BRD2 | |
| SCHEMBL16896900 | 0.83 | BRD4 (0.48) | CYP3A4CYP2C9CYP2D6CYP2C19BRD4 | |
| SCHEMBL16897775 | 0.81 | BRD4 (0.44) | CYP3A4CYP2C9CYP2D6CYP2C19EZH2 | |
| SCHEMBL18317138 | 0.80 | BRD4 (0.41) | CYP3A4CYP2C9EZH2BRD4BRD2 | |
| SCHEMBL16896866 | 0.80 | BRD4 (0.42) | CYP3A4CYP2C9CYP2D6CYP2C19EZH2 | |
| SCHEMBL18317114 | 0.79 | BRD4 (0.41) | CYP3A4CYP2C9EZH2BRD4BRD2 | |
| SCHEMBL16896794 | 0.78 | BRD4 (0.43) | CYP3A4CYP2C9CYP2D6CYP2C19BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015104653-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-16 | — | — | WO | disclosed |