Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 11/20 | 0.59 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16906540 | 0.81 | KCNJ1 (0.63) | KCNJ1SRD5A1TSHR | |
| SCHEMBL19117259 | 0.77 | KCNJ1 (0.59) | KCNJ1SRD5A1TSHRAVPR1A | |
| SCHEMBL19118083 | 0.77 | KCNJ1 (0.59) | KCNJ1 | |
| SCHEMBL8115187 | 0.77 | KCNJ1 (0.59) | KCNJ1SRD5A1TSHR | |
| SCHEMBL17442942 | 0.76 | KCNJ1 (0.51) | KCNJ1TSHR | |
| SCHEMBL17442935 | 0.76 | KCNJ1 (0.54) | KCNJ1SRD5A1TSHRHSD17B3 | |
| SCHEMBL16906602 | 0.75 | KCNJ1 (1.00) | KCNJ1 | |
| SCHEMBL17442915 | 0.75 | KCNJ1 (0.53) | KCNJ1 | |
| SCHEMBL11772012 | 0.71 | CYP11B2 (0.56) | SRD5A1ROCK1TSHRHSD17B3AVPR1A | |
| SCHEMBL13727392 | 0.70 | CYP11B2 (0.56) | TSHRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109608457-B | Medicine for treating pneumonia and preparation method thereof | 牡丹江医学院 | 2020-05-12 | — | — | CN | disclosed |
| EP-3169672-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2020-04-29 | — | — | EP | disclosed |
| US-10208064-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. | 2019-02-19 | — | — | US | disclosed |
| EP-3092230-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2018-07-11 | — | — | EP | disclosed |
| EP-3092230-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2018-07-11 | — | — | EP | disclosed |
| US-9718808-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9718808-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9718808-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170197989-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2017-07-13 | — | — | US | disclosed |
| EP-3169672-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2017-05-24 | — | — | EP | disclosed |
| US-20170037037-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2017-02-09 | — | — | US | disclosed |
| US-20170037037-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2017-02-09 | — | — | US | disclosed |
| US-20170037037-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2017-02-09 | — | — | US | disclosed |
| EP-3092230-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2016-11-16 | — | — | EP | disclosed |
| WO-2016010802-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2016-01-21 | — | — | WO | disclosed |
| WO-2016008064-A1 | INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2016-01-21 | — | — | WO | disclosed |
| WO-2015105736-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2015-07-16 | — | — | WO | disclosed |
| WO-2015105736-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2015-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208064-B2 | Inhibitors of the renal outer medullary potassium channel | KCNJ11, KCNJ1, KCNJ2 | KCNJ1 2/4885SRD5A1 845/4885ROCK1 698/4885 |
| US-20170197989-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | KCNJ1 2/4885SRD5A1 845/4885ROCK1 698/4885 |
| US-20170037037-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | KCNJ1 2/4885SRD5A1 845/4885ROCK1 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.