Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21737915 | 0.89 | BACE1 (0.48) | BACE1RENCYP2D6CTSKCTSS | |
| SCHEMBL30910800 | 0.89 | BACE1 (0.48) | BACE1RENCYP2D6CTSKCTSS | |
| SCHEMBL30511412 | 0.89 | BACE1 (0.48) | BACE1RENCYP2D6CTSKCTSS | |
| Hydrochloric Acid SCHEMBL30511421 | 0.88 | BACE1 (0.48) | BACE1RENCYP2D6CTSKCTSS | |
| SCHEMBL16899124 | 0.86 | CYP1A2 (0.44) | BACE1CYP2D6CTSKCTSSCTSL | |
| SCHEMBL21724228 | 0.84 | BACE1 (0.51) | BACE1RENCTSKCTSSCTSL | |
| SCHEMBL21724565 | 0.84 | BACE1 (0.51) | BACE1RENCTSKCTSSCTSL | |
| SCHEMBL21724562 | 0.84 | BACE1 (0.51) | BACE1RENCTSKCTSSCTSL | |
| SCHEMBL9980636 | 0.84 | BACE1 (0.51) | BACE1RENCTSKCTSSCTSL | |
| Hydrochloric Acid SCHEMBL21724540 | 0.83 | BACE1 (0.50) | BACE1RENCTSKCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49816-E1 | Dipeptides as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2024-01-30 | — | — | US | disclosed |
| EP-3092244-B1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | UNIV CORNELL (US) | 2019-08-14 | — | — | EP | disclosed |
| US-9988421-B2 | Dipeptides as inhibitors of human immunoproteasomes | CORNELL UNIVERSITY (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | CORNELL UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
| EP-3092244-A2 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | Cornell University (US) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015106200-A2 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | CORNELL UNIVERSITY (US) | 2015-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121366-A1 | DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES | DNPEP, PSMB10, DPEP1 | BACE1 337/4885REN 532/4885CYP2D6 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.