Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 3/20 | 0.54 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.54 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.54 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.54 |
| ▸ | EZH2 | Q15910 | 17/20 | 0.51 |
| ▸ | EZH1 | Q92800 | 7/20 | 0.46 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.43 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594829 | 0.85 | EZH2 (0.67) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899521 | 0.83 | EED (0.57) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL2595098 | 0.79 | EZH2 (0.66) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899422 | 0.78 | EZH2 (0.68) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899574 | 0.77 | EED (0.53) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899555 | 0.74 | EZH2 (0.64) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16742197 | 0.73 | EZH2 (0.55) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL2595322 | 0.73 | EZH2 (0.73) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899528 | 0.73 | EED (0.54) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16742146 | 0.72 | EED (0.54) | EEDRBBP4SUZ12AEBP2EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | claimed |
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |