Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 3/20 | 0.54 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.54 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.54 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.54 |
| ▸ | EZH2 | Q15910 | 18/20 | 0.51 |
| ▸ | EZH1 | Q92800 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16899521 | 0.86 | EED (0.57) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899555 | 0.84 | EZH2 (0.64) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL2595121 | 0.84 | EZH2 (0.63) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899574 | 0.82 | EED (0.53) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL14717700 | 0.81 | EZH2 (0.62) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL12180087 | 0.81 | EZH2 (0.62) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL12180130 | 0.80 | EZH2 (0.51) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL16899537 | 0.80 | EZH2 (0.68) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL17956110 | 0.77 | EZH2 (0.55) | EEDRBBP4SUZ12AEBP2EZH2 | |
| SCHEMBL12180104 | 0.77 | EZH2 (0.53) | EEDRBBP4SUZ12AEBP2EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | claimed |
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |