Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.58 |
| ▸ | EED | O75530 | 2/20 | 0.45 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.45 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.45 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.45 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16899512 | 0.92 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899658 | 0.86 | EZH2 (0.78) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899587 | 0.86 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899482 | 0.82 | EZH2 (0.67) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899584 | 0.80 | EZH2 (0.53) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899531 | 0.80 | EZH2 (0.82) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899643 | 0.78 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899650 | 0.78 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899575 | 0.78 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899574 | 0.78 | EED (0.53) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | claimed |
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |