Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 3/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16899449 | 0.77 | CYP19A1 (0.39) | MYCNR4A1EPRS1MEN1KMT2A | |
| SCHEMBL16899455 | 0.73 | NOTUM (0.33) | MYCNR4A1EPRS1 | |
| SCHEMBL2592220 | 0.73 | HAAO (0.38) | MYCKDM4EHCAR3EZH2ALDH1A1 | |
| SCHEMBL2594898 | 0.71 | NR4A1 (0.38) | MYCNR4A1MEN1KMT2AKDM4E | |
| SCHEMBL21438922 | 0.71 | HCAR3 (0.41) | KDM4EHCAR3CA12CA1CA2 | |
| SCHEMBL17970548 | 0.70 | KDM4A (0.41) | MYCKDM4EALDH1A1CA12CA1 | |
| SCHEMBL14727054 | 0.69 | EZH2 (0.40) | MYCKDM4EHCAR3EZH2GAA | |
| SCHEMBL22939471 | 0.68 | TTR (0.41) | NR4A1MEN1KMT2AKDM4EHCAR3 | |
| SCHEMBL30500734 | 0.68 | NOTUM (0.50) | MYCNR4A1MEN1KMT2AKDM4E | |
| SCHEMBL2594989 | 0.67 | MAPT (0.43) | MYCKMT2AKDM4ETDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |