⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1690776 | 1.00 | — | — | |
| SCHEMBL3682344 | 0.77 | POLB (0.35) | — | |
| SCHEMBL2237730 | 0.76 | POLB (0.43) | — | |
| SCHEMBL1690997 | 0.72 | ELANE (0.31) | — | |
| SCHEMBL1690974 | 0.72 | ELANE (0.31) | — | |
| SCHEMBL1691038 | 0.69 | — | — | |
| SCHEMBL1691035 | 0.69 | — | — | |
| SCHEMBL1691565 | 0.69 | — | — | |
| SCHEMBL637338 | 0.67 | LMNA (0.47) | — | |
| SCHEMBL17426002 | 0.67 | POLB (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353057-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20130131355-A1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | XENOPORT, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| US-8378137-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377956-B2 | Use of (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl) butanoic acid for treating urinary incontinence | XENOPORT, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120010425-A1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | XENOPORT, INC. (US) | 2012-01-12 | — | — | US | disclosed |
| WO-2011109403-A1 | USE OF (3R)-4-{[(1S)-2-METHYL-1- (2-METHYLPROPANOYLOXY)PROPOXY]CARBONYLAMINO}-3-(4-CHLOROPHENYL) BUTANOIC ACID FOR TREATING URINARY INCONTINENCE | XENOPORT, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| US-20110212984-A1 | USE OF (3R)-4--3-(4-CHLOROPHENYL) BUTANOIC ACID FOR TREATING URINARY INCONTINENCE | XENOPORT, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-8003809-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20090216037-A1 | Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof | XENOPORT, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-7511158-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070244331-A1 | Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof | XENOPORT, INC. | 2007-10-18 | — | — | US | disclosed |
| US-20070037988-A9 | Formation of a thiocarbamate from a haloformic compound, dehalo-esterification, coupling an N-hydroxysuccinimide or secondary amide-containing drug; prodrugs of gabapentin and baclofen; improved bioavailability | XENOPORT, INC. | 2007-02-15 | — | — | US | disclosed |
| EP-1716115-A2 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | Xenoport, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20050222431-A1 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. | 2005-10-06 | — | — | US | disclosed |
| WO-2005066122-A2 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | XENOPORT, INC. (US) | 2005-07-21 | — | — | WO | disclosed |