Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.86 |
| ▸ | KDM5C | P41229 | 8/20 | 0.86 |
| ▸ | KDM5A | P29375 | 7/20 | 0.86 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.86 |
| ▸ | KDM4A | O75164 | 2/20 | 0.74 |
| ▸ | KDM6B | O15054 | 1/20 | 0.74 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.74 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.72 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29373338 | 0.93 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637431 | 0.93 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16291430 | 0.92 | KDM5B (0.83) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637682 | 0.89 | KDM5B (0.86) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18708524 | 0.88 | KDM5B (0.83) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16291798 | 0.87 | KDM5B (0.81) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637410 | 0.87 | KDM5B (0.81) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18286846 | 0.86 | KDM5B (0.80) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676368 | 0.86 | KDM5B (0.80) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15636679 | 0.85 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |