Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.69 |
| ▸ | GSK3B | P49841 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 5/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.65 |
| ▸ | BRAF | P15056 | 4/20 | 0.65 |
| ▸ | ARAF | P10398 | 2/20 | 0.65 |
| ▸ | RET | P07949 | 3/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603585 | 0.91 | RAF1 (0.71) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13603514 | 0.91 | RAF1 (0.71) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13603523 | 0.90 | RAF1 (0.69) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13603517 | 0.89 | RAF1 (0.70) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL171199 | 0.89 | RAF1 (0.81) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13603512 | 0.88 | RAF1 (0.68) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13603510 | 0.86 | RAF1 (0.68) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL26923233 | 0.86 | RAF1 (0.78) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3707691 | 0.85 | RAF1 (0.83) | RAF1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL104548 | 0.83 | CA7 (0.63) | RAF1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158076-A1 | Methylene Urea Derivatives | MERCK PATENT GMBH (DE) | 2013-06-20 | — | — | US | disclosed |
| US-8410143-B2 | Methylene urea derivatives | MERCK PATENT GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8410143-B2 | Methylene urea derivatives | MERCK PATENT GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | BRAF, RAF1, CMPK1 | RAF1 2/4885HDAC3 3570/4885HDAC4 2841/4885 |
| US-20130158076-A1 | Methylene Urea Derivatives | BRAF, RAF1, CMPK1 | RAF1 2/4885HDAC3 3570/4885HDAC4 2841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.