Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.78 |
| ▸ | GSK3B | P49841 | 2/20 | 0.75 |
| ▸ | KDR | P35968 | 4/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.73 |
| ▸ | ARAF | P10398 | 2/20 | 0.73 |
| ▸ | BRAF | P15056 | 2/20 | 0.73 |
| ▸ | RET | P07949 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.73 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | MUSK | O15146 | 1/20 | 0.73 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.73 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.73 |
| ▸ | MLNR | O43193 | 1/20 | 0.73 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.73 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.73 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.73 |
| ▸ | PDE6D | O43924 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26921335 | 0.92 | GSK3B (0.78) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL2480623 | 0.88 | RAF1 (0.84) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL13471762 | 0.88 | RAF1 (0.84) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL13471761 | 0.88 | RAF1 (0.84) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL13603517 | 0.88 | RAF1 (0.70) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL3707691 | 0.88 | RAF1 (0.83) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL937568 | 0.88 | RAF1 (1.00) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL22360885 | 0.87 | KDR (0.71) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL13603512 | 0.87 | RAF1 (0.68) | RAF1GSK3BKDRPDGFRBARAF | |
| SCHEMBL3407760 | 0.86 | KDR (0.84) | RAF1GSK3BKDRPDGFRBARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240093191-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2024-03-21 | — | — | US | disclosed |
| EP-4288539-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | Research Institute at Nationwide Children's Hospital (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169922-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2022-08-11 | — | — | WO | disclosed |