Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDIT3 | P35638 | 15/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | MITF | O75030 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16912991 | 0.92 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16912990 | 0.92 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16913004 | 0.91 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16919789 | 0.89 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16912994 | 0.89 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16913006 | 0.88 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16919773 | 0.87 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16919786 | 0.86 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16913001 | 0.84 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB | |
| SCHEMBL16919794 | 0.82 | DDIT3 (1.00) | DDIT3RAB9AMAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2020-09-29 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | IAPP, TFEB, GBA1 | DDIT3 30/4885RAB9A 1553/4885MAPT 417/4885 |
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | IAPP, TFEB, GBA1 | DDIT3 30/4885RAB9A 1553/4885MAPT 417/4885 |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | IAPP, TFEB, GBA1 | DDIT3 30/4885RAB9A 1553/4885MAPT 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.