TFEB

Transcription factor EB · P19484 · TFEB on Sugi Atlas →

2,275 patent compounds predicted against TFEB, 1,820 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2744044	1.00	1/20
SCHEMBL2744047	1.00	1/20
SCHEMBL609603	0.78	1/20
SCHEMBL609604	0.78	1/20
Coumarinic Acid Methyl Ether (SCHEMBL79060)	0.77	1/20
Coumarinic Acid Methyl Ether (SCHEMBL83064)	0.77	1/20
SCHEMBL644526	0.77	1/20
SCHEMBL644527	0.77	1/20
Coumarinic Acid Methyl Ether (SCHEMBL714857)	0.77	1/20
SCHEMBL1379749	0.74	1/20
SCHEMBL1397474	0.74	1/20
SCHEMBL1477685	0.74	1/20
SCHEMBL1477777	0.74	1/20
SCHEMBL1569425	0.74	1/20
SCHEMBL1569432	0.74	1/20
Coumarinic Acid Methyl Ether (SCHEMBL4743620)	0.74	1/20
SCHEMBL5598849	0.74	1/20
SCHEMBL5598851	0.74	1/20
SCHEMBL6737719	0.74	1/20
SCHEMBL7068436	0.74	1/20

Clinical trials — most relevant to TFEB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients	PHASE4	UNKNOWN
A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes	PHASE3	COMPLETED
Azithromycin Plus Hydroxychloroquine for COVID-19 Infection	PHASE3	WITHDRAWN
FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer	PHASE1/PHASE2	COMPLETED
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients	PHASE2	UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Nilotinib in Huntington's Disease	PHASE1	UNKNOWN
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction	EARLY_PHASE1	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)	nan	RECRUITING
Time Course for Fasting-induced Autophagy in Humans	nan	WITHDRAWN
Autophagy Bladder Cancer	nan	UNKNOWN
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
2-A-Day Study: Twice a Day Meals Study.	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Strong Evidence: Digitally Delivered Exercise in Older Adults	nan	ACTIVE_NOT_RECRUITING
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Nasturtium (Tropaeolum Majus L) Intake and Biochemical Parameters in Pre-diabetic Subjects in Bogota Colombia	nan	COMPLETED
Autophagy/Apoptosis Balance in Placental Vascular Pathologies	nan	RECRUITING
Muscle Insulin Resistance in Aging (Mirage)	nan	ACTIVE_NOT_RECRUITING
The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy	nan	COMPLETED
Studying Samples From Patients With T-Cell Acute Lymphoblastic Leukemia	nan	COMPLETED
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TFEB binder may also engage these)

Protein	Name	Similarity
Q05B92	—	1.000	Q05B92 →
Q9R210	—	1.000	Q9R210 →
Q08874	—	1.000	Q08874 →
P23899	—	0.999	P23899 →
Q9GZV5	—	0.999	Q9GZV5 →
Q9XUK2	—	0.999	Q9XUK2 →
Q2EJA0	—	0.998	Q2EJA0 →
Q58NQ4	—	0.998	Q58NQ4 →
O14948	—	0.998	O14948 →
A0A8C0NGY6	—	0.998	A0A8C0NGY6 →
Q9H334	—	0.997	Q9H334 →
Q4VYR7	—	0.997	Q4VYR7 →
P40425	—	0.997	P40425 →
Q68F77	—	0.997	Q68F77 →
H2LBU8	—	0.997	H2LBU8 →
A2T713	—	0.997	A2T713 →
Q6NSM8	—	0.997	Q6NSM8 →
P35680	—	0.997	P35680 →
Q5XFQ6	—	0.997	Q5XFQ6 →
P24610	—	0.997	P24610 →
Q1L8J7	—	0.997	Q1L8J7 →
Q9PVZ3	—	0.997	Q9PVZ3 →
P31363	—	0.997	P31363 →
P27889	—	0.997	P27889 →
P54655	—	0.997	P54655 →
Q9DE25	—	0.997	Q9DE25 →
Q91660	—	0.997	Q91660 →
Q28EM1	—	0.996	Q28EM1 →
P40645	—	0.996	P40645 →
Q6YHU8	—	0.996	Q6YHU8 →