Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | WHR1 | P49842 | 4/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | ROS1 | P08922 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058388 | 0.92 | PDE4D (0.33) | PDE4DTNF | |
| Trifluoroacetic Acid SCHEMBL17019863 | 0.82 | GPR6 (0.40) | GPR6PDE4DWHR1DPP4DPP8 | |
| SCHEMBL1203280 | 0.82 | PDE4D (0.36) | PDE4DTNFEGLN1 | |
| Trifluoroacetic Acid SCHEMBL16924608 | 0.81 | DPP4 (0.30) | DPP4DPP8 | |
| SCHEMBL16494111 | 0.80 | PDE4D (0.36) | PDE4DTNFEGLN1 | |
| Trifluoroacetic Acid SCHEMBL16924600 | 0.79 | DPP4 (0.31) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL16924605 | 0.79 | EP300 (0.34) | GPR6WHR1 | |
| SCHEMBL12879606 | 0.79 | MAP3K12 (0.42) | PDE4DTNFMAP3K12 | |
| SCHEMBL1202978 | 0.78 | SMO (0.38) | GPR6PDE4DTNFEGLN1 | |
| SCHEMBL8059042 | 0.78 | PDE4D (0.34) | PDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090626-B2 | Piperazino-dihydrothienopyrimidine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-28 | — | — | US | disclosed |