Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 17/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694460 | 1.00 | USP1 (0.63) | USP1JAK2JAK3JAK1FYN | |
| SCHEMBL1693668 | 0.84 | JAK2 (0.56) | USP1JAK2JAK3JAK1 | |
| SCHEMBL1693663 | 0.84 | JAK2 (0.56) | USP1JAK2JAK3JAK1 | |
| SCHEMBL12069376 | 0.81 | USP1 (0.41) | USP1JAK2JAK3JAK1 | |
| SCHEMBL12069389 | 0.79 | USP1 (0.39) | USP1JAK2JAK3JAK1 | |
| SCHEMBL29769520 | 0.78 | USP1 (1.00) | USP1JAK2JAK3JAK1 | |
| SCHEMBL29769502 | 0.78 | USP1 (1.00) | USP1JAK2JAK3JAK1 | |
| SCHEMBL18865923 | 0.78 | USP1 (1.00) | USP1JAK2JAK3JAK1 | |
| SCHEMBL18865925 | 0.78 | USP1 (1.00) | USP1JAK2JAK3JAK1 | |
| SCHEMBL18866000 | 0.78 | USP1 (1.00) | USP1JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582703-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157397-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-12-22 | — | — | WO | disclosed |