USP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1185172	0.58	19/20
SCHEMBL1693418	0.50	19/20
SCHEMBL1693251	0.50	18/20
SCHEMBL1693260	0.50	18/20
SCHEMBL1693166	0.63	17/20
SCHEMBL1694460	0.63	17/20
SCHEMBL786104	0.62	15/20
SCHEMBL786218	0.55	15/20
SCHEMBL786367	0.55	15/20
SCHEMBL786256	0.64	14/20
SCHEMBL786464	0.64	14/20
SCHEMBL786568	0.62	14/20
SCHEMBL785772	0.61	14/20
SCHEMBL786583	0.60	14/20
SCHEMBL801853	0.60	14/20
SCHEMBL786508	0.58	14/20
SCHEMBL786182	0.57	14/20
SCHEMBL786812	0.57	14/20
SCHEMBL785641	0.56	14/20
SCHEMBL786042	0.56	14/20

Clinical trials — most relevant to USP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy	PHASE2	NOT_YET_RECRUITING
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
A Study of UBT251 in Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH)	PHASE2	RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome	PHASE1	RECRUITING
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis	nan	NOT_YET_RECRUITING
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma	nan	COMPLETED
Clinical Trial of Levodopa/Carbidopa ( Sinemet) Therapy in Angel Man Syndrome	nan	COMPLETED
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome	nan	RECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Neuronal and Glial Biomarkers in Stroke	nan	COMPLETED
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries	nan	RECRUITING
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis	nan	UNKNOWN
A Natural History Study of Angelman Syndrome	nan	RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer's Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a USP1 binder may also engage these)

Protein	Name	Similarity
Q569C3	—	1.000	Q569C3 →
Q29RP1	—	1.000	Q29RP1 →
Q8BJQ2	—	0.998	Q8BJQ2 →
Q6DFV7	—	0.987	Q6DFV7 →
Q8RWK8	—	0.985	Q8RWK8 →
P62292	—	0.985	P62292 →
Q9Z2U2	—	0.985	Q9Z2U2 →
Q6ZV73	—	0.985	Q6ZV73 →
Q6KAQ7	—	0.985	Q6KAQ7 →
Q9NYI0	—	0.985	Q9NYI0 →
WAPL	Wings apart-like protein homolog	0.985	landscape →
P62291	—	0.985	P62291 →
Q5W0B1	—	0.985	Q5W0B1 →
A6QP06	—	0.984	A6QP06 →
Q8BL06	—	0.984	Q8BL06 →
Q80Y19	—	0.984	Q80Y19 →
KMT5B	Histone-lysine N-methyltransferase KMT5B	0.984	landscape →
Q8WZ64	—	0.984	Q8WZ64 →
Q5FBB7	—	0.984	Q5FBB7 →
DCLRE1A	DNA cross-link repair 1A protein	0.984	landscape →
P62287	—	0.983	P62287 →
P62290	—	0.983	P62290 →
A8MW92	—	0.983	A8MW92 →
Q6P4F7	—	0.983	Q6P4F7 →
Q2PFD7	—	0.983	Q2PFD7 →
D3ZU96	—	0.983	D3ZU96 →
A0JMT0	—	0.983	A0JMT0 →
Q8WML3	—	0.983	Q8WML3 →
Q13129	—	0.983	Q13129 →
Q5QJC4	—	0.983	Q5QJC4 →