Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.76 |
| ▸ | PRKCA | P17252 | 10/20 | 0.76 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.76 |
| ▸ | EGFR | P00533 | 3/20 | 0.76 |
| ▸ | BCR | P11274 | 14/20 | 0.62 |
| ▸ | SRC | P12931 | 8/20 | 0.62 |
| ▸ | PRKACA | P17612 | 1/20 | 0.62 |
| ▸ | PRKACG | P22612 | 1/20 | 0.62 |
| ▸ | PRKACB | P22694 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | PRKCG | P05129 | 2/20 | 0.58 |
| ▸ | PRKCB | P05771 | 2/20 | 0.58 |
| ▸ | PRKCH | P24723 | 2/20 | 0.58 |
| ▸ | PRKCI | P41743 | 2/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.58 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262145 | 0.87 | ABL1 (1.00) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL29618427 | 0.85 | ABL1 (0.85) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL6859862 | 0.85 | ABL1 (0.71) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7476133 | 0.83 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL3868291 | 0.83 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7461475 | 0.83 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7464205 | 0.83 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL16932353 | 0.82 | ABL1 (0.67) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7532338 | 0.82 | ABL1 (0.71) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL3085556 | 0.82 | ABL1 (0.66) | ABL1PRKCAPRKCDEGFRBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100406452-C | N-phenyl-2-pyrimidinamine derivatives | NOVARTIS AG (CH) | 2008-07-30 | — | — | CN | claimed |
| US-9579365-B2 | Therapeutic ribonucleases | QUINTESSENCE BIOSCIENCES, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150209415-A1 | THERAPEUTIC RIBONUCLEASES | QUINTESSENCE BIOSCIENCES, INC. | 2015-07-30 | — | — | US | disclosed |
| CN-102372690-B | Intermediate for synthesizing imatinib and application of intermediate in imatinib synthesis | CHENGDU DIAO PHARMACEUTICAL GROUP CO LTD | 2014-05-28 | — | — | CN | disclosed |