Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16934064 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AL3MBTL1SPHK2 | |
| SCHEMBL15175334 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AL3MBTL1SPHK2 | |
| SCHEMBL16934066 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AL3MBTL1SPHK2 | |
| SCHEMBL15175333 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AL3MBTL1SPHK2 | |
| SCHEMBL16933905 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AL3MBTL1SPHK2 | |
| SCHEMBL15176394 | 0.86 | SPHK2 (0.51) | SPHK2SPHK1CHRM2CHRM4CHRM5 | |
| SCHEMBL15175875 | 0.86 | SPHK2 (0.51) | SPHK2SPHK1CHRM2CHRM4CHRM5 | |
| SCHEMBL30147124 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AL3MBTL1SPHK2 | |
| SCHEMBL15186301 | 0.83 | SPHK2 (0.71) | SPHK2SPHK1 | |
| SCHEMBL16934338 | 0.83 | SPHK2 (0.71) | SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688668-B2 | Long chain base sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150210675-A1 | LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210675-A1 | LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS | SPHK1, SPHK2, SGPL1 | ALDH1A1 2473/4885MEN1 1594/4885KMT2A 2094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.