Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.88 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16935164 | 0.99 | EZH2 (0.87) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935167 | 0.96 | EZH2 (0.81) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL20111746 | 0.94 | EZH2 (1.00) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL31189809 | 0.94 | EZH2 (1.00) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL29412236 | 0.94 | EZH2 (1.00) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935186 | 0.92 | EZH2 (0.86) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935396 | 0.90 | EZH2 (0.83) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935191 | 0.90 | EZH2 (0.89) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935365 | 0.89 | EZH2 (0.92) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935285 | 0.89 | EZH2 (0.92) | EZH2EZH1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015110999-A1 | EZH2 INHIBITORS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2015-07-30 | — | — | WO | claimed |
| WO-2015110999-A1 | EZH2 INHIBITORS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2015-07-30 | — | — | WO | disclosed |