Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 19/20 | 1.00 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31189809 | 1.00 | EZH2 (1.00) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL29412236 | 1.00 | EZH2 (1.00) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935365 | 0.96 | EZH2 (0.92) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935285 | 0.96 | EZH2 (0.92) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL24072447 | 0.94 | EZH2 (0.90) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935191 | 0.94 | EZH2 (0.89) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL16935220 | 0.94 | EZH2 (0.88) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL24071944 | 0.94 | EZH2 (0.88) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL21284965 | 0.93 | EZH2 (0.87) | EZH2EZH1HDAC1HDAC6 | |
| SCHEMBL21284967 | 0.93 | EZH2 (0.87) | EZH2EZH1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636283-B2 | Inhibition of PRC2 subunits to treat eye disorders | FONDATION ASILE DES AVEUGLES (CH) | 2026-05-26 | — | — | US | claimed |
| EP-3823671-B1 | INHIBITION OF PRC2 SUBUNITS TO TREAT EYE DISORDERS | FOND ASILE DES AVEUGLES (CH) | 2024-02-07 | — | — | EP | claimed |
| CN-113527275-A | SKLB1039 compound and preparation method and application thereof | 成都师范学院 | 2021-10-22 | — | — | CN | claimed |
| US-20210213013-A1 | INHIBITION OF PRC2 SUBUNITS TO TREAT EYE DISORDERS | FONDATION ASILE DES AVEUGLES (CH) | 2021-07-15 | — | — | US | claimed |
| US-20230114294-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2023-04-13 | — | — | US | disclosed |
| CN-113527275-A | SKLB1039 compound and preparation method and application thereof | 成都师范学院 | 2021-10-22 | — | — | CN | disclosed |
| US-20200338070-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-10-29 | — | — | US | disclosed |
| US-20190255041-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2019-08-22 | — | — | US | disclosed |
| WO-2018081530-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200338070-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | EZH2, EZH1, EED | EZH2 1/4885EZH1 2/4885HDAC1 73/4885 |
| US-12636283-B2 | Inhibition of PRC2 subunits to treat eye disorders | EZH2, EZH1, EED | EZH2 1/4885EZH1 2/4885HDAC1 136/4885 |
| US-20230114294-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | EZH2, EZH1, EED | EZH2 1/4885EZH1 2/4885HDAC1 73/4885 |
| US-20190255041-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | EZH2, EZH1, EED | EZH2 1/4885EZH1 2/4885HDAC1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.