Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543779 | 0.92 | MAPT (0.55) | MAPTCCR3OPRL1OPRM1OPRD1 | |
| SCHEMBL24422207 | 0.83 | OPRM1 (0.59) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL9910960 | 0.78 | CCR3 (0.50) | MAPTCCR3OPRL1OPRM1OPRD1 | |
| SCHEMBL3591425 | 0.78 | CCR3 (0.57) | CCR3OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL18026610 | 0.76 | CCR3 (0.60) | CCR3OPRL1OPRM1DRD2 | |
| SCHEMBL8026713 | 0.76 | OPRM1 (0.54) | MAPTOPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL24421698 | 0.76 | OPRM1 (0.49) | MAPTOPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL17886542 | 0.75 | OPRM1 (0.46) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL19462825 | 0.75 | OPRM1 (0.43) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL16936710 | 0.75 | OPRM1 (0.53) | OPRL1OPRM1OPRD1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3096754-A1 | METALLO-BETA-LACTAMASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-11-30 | — | — | EP | disclosed |
| WO-2015112441-A1 | METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-07-30 | — | — | WO | disclosed |