Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16940822 | 0.87 | HPGD (0.48) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL16940819 | 0.86 | HPGD (0.40) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL15401504 | 0.80 | CHRM2 (0.46) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL16940823 | 0.77 | CHRM2 (0.45) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL16940813 | 0.77 | USP2 (0.40) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL16940806 | 0.77 | USP2 (0.40) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL12236519 | 0.76 | CHRM2 (0.50) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL15400955 | 0.76 | USP2 (0.53) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL17122072 | 0.75 | USP2 (0.43) | CHRM2CHRM1CHRM3HPGDUSP2 | |
| SCHEMBL16940803 | 0.74 | HPGD (0.48) | CHRM2CHRM1CHRM3HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9777009-B2 | Deuterated ibrutinib | CONCERT PHARMACEUTICALS, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-20170015670-A1 | DEUTERATED IBRUTINIB | CONCERT PHARMACEUTICALS, INC. | 2017-01-19 | — | — | US | disclosed |
| US-9422295-B2 | Deuterated ibrutinib | CONCERT PHARMACEUTICALS, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150210699-A1 | Deuterated Ibrutinib | CONCERT PHARMACEUTICALS, INC. (US) | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170015670-A1 | DEUTERATED IBRUTINIB | BTK, ABL1, JAK2 | CHRM2 4846/4885CHRM1 4680/4885CHRM3 4537/4885 |
| US-20150210699-A1 | Deuterated Ibrutinib | BTK, ABL1, JAK2 | CHRM2 4852/4885CHRM1 4745/4885CHRM3 4537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.