Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17122072 | 0.87 | USP2 (0.43) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL12236519 | 0.85 | CHRM2 (0.50) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL15400955 | 0.85 | USP2 (0.53) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL17122067 | 0.85 | USP2 (0.44) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL17190705 | 0.84 | USP2 (0.43) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL17122078 | 0.80 | CHRM2 (0.49) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL16940802 | 0.80 | CHRM2 (0.41) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL12604691 | 0.78 | NR1H2 (0.41) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL12604688 | 0.78 | NR1H2 (0.44) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 | |
| SCHEMBL29558378 | 0.78 | NR1H2 (0.41) | CHRM2CHRM1CHRM3USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9707218-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9707218-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150366853-A1 | Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150366853-A1 | Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150299170-A1 | FLUORO-DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS | CONCERT PHARMACEUTICALS INC (US) | 2015-10-22 | — | — | US | disclosed |
| US-9145390-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145390-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20140005211-A1 | DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS | CONCERT PHARMACEUTICALS, INC. (US) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299170-A1 | FLUORO-DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS | ALK, ABL1, BRAF | CHRM2 4390/4885CHRM1 4693/4885CHRM3 3437/4885 |
| US-20150366853-A1 | Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds | ALK, ABL1, MALT1 | CHRM2 4449/4885CHRM1 4725/4885CHRM3 3725/4885 |
| US-20140005211-A1 | DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS | ALK, ABL1, MALT1 | CHRM2 4449/4885CHRM1 4725/4885CHRM3 3725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.