Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164587 | 0.83 | LMNA (0.41) | CA1CA2HTTLMNATP53 | |
| SCHEMBL31683734 | 0.83 | LMNA (0.41) | CA1CA2HTTLMNATP53 | |
| SCHEMBL16793738 | 0.83 | LMNA (0.41) | CA1CA2HTTLMNATP53 | |
| SCHEMBL121332 | 0.83 | LMNA (0.41) | CA1CA2HTTLMNATP53 | |
| SCHEMBL31683735 | 0.83 | LMNA (0.41) | CA1CA2HTTLMNATP53 | |
| Hydrochloric Acid SCHEMBL29873729 | 0.82 | LMNA (0.39) | CA1CA2HTTLMNATP53 | |
| Hydrochloric Acid SCHEMBL22659697 | 0.82 | LMNA (0.39) | CA1CA2HTTLMNATP53 | |
| Hydrochloric Acid SCHEMBL22659695 | 0.82 | LMNA (0.39) | CA1CA2HTTLMNATP53 | |
| Hydrochloric Acid SCHEMBL117063 | 0.82 | LMNA (0.39) | CA1CA2HTTLMNATP53 | |
| SCHEMBL169457 | 0.78 | EPHX1 (0.33) | DPP8DPP9DPP7CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424865-A2 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |
| EP-2324018-A1 | CYCLIC INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010127237-A2 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010011314-A1 | CYCLIC INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |