Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694730 | 0.99 | CDK1 (0.43) | CDK1PIK3R2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL1694805 | 0.93 | PIK3CA (0.45) | CDK1PIK3R2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL1694917 | 0.93 | CDK1 (0.45) | CDK1PIK3R2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL1694753 | 0.88 | PIK3R2 (0.39) | PIK3R2PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1694831 | 0.84 | PIK3CD (0.43) | PIK3R2PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1695139 | 0.84 | PIK3R2 (0.45) | PIK3R2PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1695297 | 0.82 | ADORA2A (0.39) | PIK3R2PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1695323 | 0.81 | PIK3CD (0.37) | PIK3R2PIK3CDHPGD | |
| SCHEMBL1695191 | 0.81 | PIK3CD (0.40) | CDK1PIK3R2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL14816051 | 0.80 | PIK3CD (0.51) | PIK3R2PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |