Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695139 | 0.90 | PIK3R2 (0.45) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1694949 | 0.89 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1694831 | 0.89 | PIK3CD (0.43) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1694728 | 0.88 | CDK1 (0.42) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1694730 | 0.87 | CDK1 (0.43) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1695256 | 0.87 | PIK3CD (0.40) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1695297 | 0.86 | ADORA2A (0.39) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1695191 | 0.86 | PIK3CD (0.40) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1694917 | 0.86 | CDK1 (0.45) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1694805 | 0.86 | PIK3CA (0.45) | PIK3R2PIK3CDPIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |