Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695295 | 0.94 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695299 | 0.93 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695073 | 0.92 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1694815 | 0.88 | DHODH (0.44) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1694855 | 0.88 | PIK3CD (0.52) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695164 | 0.88 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695119 | 0.87 | PIK3CD (0.60) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1694666 | 0.87 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1694721 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL12506233 | 0.85 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |