Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695462 | 1.00 | PARP10 (0.51) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL7705364 | 0.86 | PARP10 (0.60) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL7705577 | 0.86 | PARP10 (0.60) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695898 | 0.85 | PARP10 (0.47) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695900 | 0.85 | PARP10 (0.47) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695730 | 0.85 | PARP10 (0.44) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695733 | 0.85 | PARP10 (0.44) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695635 | 0.84 | PARP10 (0.46) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695633 | 0.84 | PARP10 (0.46) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695825 | 0.84 | GPBAR1 (0.55) | ALOX5ALOX5APPDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | claimed |