Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695635 | 1.00 | PARP10 (0.46) | PARP10SMN1; SMN2KDM4EALDH1A1GUSB | |
| SCHEMBL1695711 | 0.86 | GPBAR1 (0.50) | ALOX5ALOX5APMAPTPDE10A | |
| SCHEMBL1695756 | 0.86 | GPBAR1 (0.50) | ALOX5ALOX5APMAPTPDE10A | |
| SCHEMBL1695758 | 0.86 | GPBAR1 (0.50) | ALOX5ALOX5APMAPTPDE10A | |
| SCHEMBL1695710 | 0.86 | GPBAR1 (0.50) | ALOX5ALOX5APMAPTPDE10A | |
| SCHEMBL1695460 | 0.84 | PARP10 (0.51) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695462 | 0.84 | PARP10 (0.51) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695900 | 0.84 | PARP10 (0.47) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695898 | 0.84 | PARP10 (0.47) | PARP10SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL1695814 | 0.83 | KDM4E (0.53) | SMN1; SMN2KDM4EALDH1A1GUSBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | disclosed |