Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.54 |
| ▸ | EED | O75530 | 7/20 | 0.54 |
| ▸ | RBBP4 | Q09028 | 7/20 | 0.54 |
| ▸ | SUZ12 | Q15022 | 7/20 | 0.54 |
| ▸ | RBBP7 | Q16576 | 3/20 | 0.54 |
| ▸ | EZH1 | Q92800 | 6/20 | 0.47 |
| ▸ | AEBP2 | Q6ZN18 | 6/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694768 | 0.77 | EZH2 (0.73) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL1695613 | 0.77 | EZH2 (0.48) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12180703 | 0.72 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL1695598 | 0.71 | EZH2 (0.87) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL27983811 | 0.71 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL16116149 | 0.70 | EZH2 (0.64) | EZH2EEDRBBP4SUZ12EZH1 | |
| SCHEMBL12180083 | 0.70 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL1695481 | 0.70 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684278 | 0.70 | EZH2 (0.84) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12180482 | 0.69 | EZH2 (0.82) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566479-A1 | AZAINDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2012005805-A1 | AZAINDAZOLES | GLAXOSMITHKLINE LLC (US) | 2012-01-12 | — | — | WO | disclosed |